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Hdac3 as a Novel Orchestrator of Lipid Oxidation in the Intestine and Potential Therapeutic Target in Obesity

Grant number: 1107836 | Funding period: 2018 - 2018

Completed

Abstract

This application will seek to determine whether blocking the HDAC3 protein, specifically in the intestine, represents a novel way of controlling obesity.

Related publications (2)

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Intestinal-specific Hdac3 deletion increases susceptibility to colitis and small intestinal tumor development in mice fed a high-fat diet

Irvin Ng, Ian Y Luk, Rebecca Nightingale, Camilla M Reehorst, Mercedes Davalos-Salas, Laura J Jenkins, Chun Fong, David S Williams, Matthew J Watt, Amardeep S Dhillon, John M Mariadason

2023-12-03

High-fat (HF) diets (HFDs) and inflammation are risk factors for colon cancer; however, the underlying mechanisms remain to be ful..

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Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate

N Pujara, S Jambhrunkar, KY Wong, M McGuckin, A Popat

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The polyphenolic compound resveratrol has received significant attention due to its many pharmacological actions such as anti-canc..

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